Op-cbio130491 2744..2749
نویسندگان
چکیده
Summary: Although the 1000 Genomes haplotypes are the most commonly used reference panel for imputation, medical sequencing projects are generating large alternate sets of sequenced samples. Imputation in African Americans using 3384 haplotypes from the Exome Sequencing Project, compared with 2184 haplotypes from 1000 Genomes Project, increased effective sample size by 8.3–11.4% for coding variants with minor allele frequency 51%. No loss of imputation quality was observed using a panel built from phenotypic extremes. We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2’s two-
منابع مشابه
Historical Development of Antihypertensive Treatment
Growth of Knowledge in the Nineteenth Century, 2742 The Measurement of Blood Pressure, 2743 Forerunners of Modern Treatment, 2743 Low-Salt Diets, 2743 Surgical Sympathectomy, 2744 The Beginnings of Drug Treatment, 2744 Ganglion-Blocking Drugs, 2745 Veratrum Viride, Hydrazaline, and Reserpine, 2746 The Modern Era of Antihypertensive Drugs, 2747 Thiazide Diuretics, 2747 Guanethidine and Alpha-Met...
متن کاملA Comparison of Radio and X-Ray Morphologies of Four Clusters of Galaxies Containing Radio Halos
Clusters of galaxies may contain cluster-wide, centrally located, diffuse radio sources, called halos. They have been found to show morphologies similar to those of the X-ray emission. To quantify this qualitative statement we performed a point-to-point comparison of the radio and the X-ray emission for four clusters of galaxies containing radio halos: Coma, Abell 2255, Abell 2319, Abell 2744. ...
متن کامل"Remarkable improvement": sulfa drugs and pediatric meningococcal meningitis, 1937-1949.
Lauded as one of the greatest developments of 20th-century medicine, the “wonder drug” penicillin reshaped the treatment of infectious diseases and altered patterns of mortality. As a result, the breakthrough that preceded penicillin—the development of the sulfonamides—is often overlooked.1–3 Using records from Sydenham Hospital, amunicipal communicable disease institution in Baltimore, Marylan...
متن کامل